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Will & Grace are best friends. Will is a gay lawyer and Grace is a straight interior designer. They both live in New York. Grace is engaged to a real jerk, but when that relationship falls apart, she moves in with Will. This is only supposed to be until Grace finds a place of her own, but she and Will end up with each other as permanent roommates. Also in the cast are Jack, Will's flamboyant gay friend and Karen, Graces' secretary/assistant who doesn't really need to work because she married money several times.。亚瑟和塞萨尔自小在学校相识，是一对性格迥异的挚友。长大后塞萨尔浪荡而活，坚信“活在当下”；而亚瑟是一名已离异的研究员，严谨度日。某日因背伤，亚瑟带塞萨尔入院检查，意外得知塞萨尔患有肺癌，寿命无多。亚瑟找机会想将这个噩耗告知塞萨尔，却被塞萨尔误解是亚瑟得了肺癌，悲痛昏倒。醒来后，塞萨尔发誓会在亚瑟身边陪他度过生命最后的日子，一对挚友怀揣着各自的愿望，开启了生命最后的疯狂旅程……《今生最好的朋友》由亚历山大·德·拉·巴特里耶与马修·得拉波特共同执导，法国演员法布莱斯·鲁奇尼，法国著名歌手兼演员帕特里克·布鲁尔共同主演。电影以独特的喜剧手法讲述了两位老男孩的花样“抗癌”路，“神仙友情”温情幽默，感人至深。《今生最好的朋友》于2020年金鸡国际影展与国内观众见面，提名最受观众喜爱影片，并收获当届影展最受观众喜爱导演奖。。